Endocrine Abstracts

Introduction: Type 1 diabetes mellitus is one of the most common chronic diseases in children. Precise knowledge of the pathogenesis of diabetes mellitus type 1 and its chronic complications is the enormous challenge in modern diabetology. In recent years, the role of leptin in the pathogenesis of microvascular diabetic complications has been highlighted.Aim: The aim of the study was to investigate serum leptin level and correlations between leptin level...

Introduction: Alopecia areata affects 0.1–0.2% of population. It’s pathogenesis has not yet been discovered, but genetic, autoimmune, vascular, psychogenic or neurological factors are being considered. It can occur in any age, but appears most commonly in late childhood, teenage or early adulthood. Alopecia areata commonly coexists with other diseases such as asthma, allergic rhinitis, atopic dermatitis, thyroid diseases and autoimmune diseases such as thyroiditis an...

The prevalence of GD (Graves–Basedow disease) in adolescents with T1DM (type 1 diabetes mellitus) is around 0.5%. Most often the diagnosis of GD in T1DM patients is made many years after the onset of T1DM. The present clinical case describes an adolescent with GD and T1DM and highlights how difficult the management of this disease can be. 17-year-old male was referred to our Department for reevaluation of Graves–Basedow disease. Patient suffered from T1DM for 14 year...

Forkhead box P3 (Foxp3) is an important regulatory factor for the development and function of T regulatory cells (Tregs). Moreover it has been established that deficiency of the Foxp3 gene in Treg cells suppresses their regulatory function leading to the development of autoimmune thyroid diseases (AITDs). The aim of our study was to estimate the association of three polymorphism of FOXP3 gene with the predisposition to GD and HT in children.<p class="abst...